Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6769878 | 0.91 | MEN1 (0.41) | ALDH1A1TSHRMAPK1MEN1KMT2A | |
| SCHEMBL6767380 | 0.89 | TSHR (0.44) | TSHR | |
| SCHEMBL6770849 | 0.87 | MEN1 (0.44) | ALDH1A1ATMTSHRMAPK1MEN1 | |
| SCHEMBL6770228 | 0.86 | MEN1 (0.42) | ALDH1A1ATMTSHRMAPK1MEN1 | |
| SCHEMBL6944953 | 0.84 | ATM (0.37) | ALDH1A1KDM4EGPBAR1ATMTSHR | |
| SCHEMBL6770762 | 0.82 | ALDH1A1 (0.41) | ALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL6766054 | 0.80 | MEN1 (0.42) | ALDH1A1ATMTSHRMAPK1MEN1 | |
| SCHEMBL6770097 | 0.79 | CA1 (0.42) | ALDH1A1TSHRMAPK1MEN1KMT2A | |
| SCHEMBL6766521 | 0.79 | TSHR (0.46) | ALDH1A1KDM4ETSHRMAPK1MEN1 | |
| SCHEMBL6766316 | 0.79 | MAPK1 (0.38) | ALDH1A1ATMTSHRMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699877-B2 | TREATING PAIN, MIGRAINE, AND VARIOUS OTHER DISEASES | GRUENENTHAL GMBH (DE) | 2004-03-02 | — | — | US | disclosed |
| US-20030087926-A1 | Substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acid derivatives | GRUENENTHAL GMBH | 2003-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030087926-A1 | Substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acid derivatives | SDHA, CACNA1A, GRIN2C | ALDH1A1 454/4885KDM4E 2022/4885GPBAR1 130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.