Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 4/20 | 0.70 |
| ▸ | TP53 | P04637 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | USP5 | P45974 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20772177 | 0.88 | TP53 (0.75) | LSSTP53RAB9ATSHRUSP5 | |
| SCHEMBL7401658 | 0.82 | LSS (1.00) | LSS | |
| SCHEMBL1387276 | 0.80 | LSS (0.94) | LSSTSHRALDH1A1 | |
| SCHEMBL7662833 | 0.80 | TP53 (0.62) | LSSTP53USP5 | |
| SCHEMBL5311528 | 0.79 | CNR1 (0.74) | LSSALDH1A1 | |
| SCHEMBL6184180 | 0.79 | LSS (0.92) | LSSNPC1RAB9ATSHRHPGD | |
| SCHEMBL6981358 | 0.79 | LSS (0.61) | LSSNPC1RAB9ATSHRHPGD | |
| SCHEMBL7660042 | 0.78 | LSS (0.77) | LSSALDH1A1 | |
| SCHEMBL7336119 | 0.77 | LSS (1.00) | LSSTSHRALDH1A1 | |
| SCHEMBL7442077 | 0.76 | LSS (0.73) | LSSHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966462-B1 | HETEROCYCLIC COMPOUNDS USEFUL AS OXIDO-SQUALENE CYCLASE INHIBITORS | ASTRAZENECA AB (SE) | 2003-06-11 | — | — | EP | disclosed |
| US-6391880-B1 | ANTICHOLESTEROL AGENTS | ZENECA LIMITED (GB) | 2002-05-21 | — | — | US | disclosed |
| EP-0966462-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS OXIDO-SQUALENE CYCLASE INHIBITORS | ZENECA LIMITED (GB) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998035959-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS OXIDO-SQUALENE CYCLASE INHIBITORS | ZENECA LIMITED (GB) | 1998-08-20 | — | — | WO | disclosed |