Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | CNR1 | P21554 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8312020 | 0.95 | NPC1 (0.61) | LSSNPC1RAB9ATSHRCNR1 | |
| SCHEMBL6179932 | 0.90 | LSS (0.65) | LSSNPC1RAB9ACNR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6978211 | 0.86 | CNR1 (0.72) | NPC1RAB9ATSHRCNR1HTT | |
| SCHEMBL5311528 | 0.85 | CNR1 (0.74) | LSSCNR1ALDH1A1L3MBTL1 | |
| SCHEMBL3824011 | 0.80 | MAPT (0.69) | TSHRHTTALDH1A1 | |
| Hydrochloric Acid SCHEMBL6977538 | 0.80 | GPR183 (0.59) | ALDH1A1L3MBTL1 | |
| SCHEMBL6955039 | 0.79 | ALDH1A1 (0.68) | LSSTSHREPHX2ALDH1A1 | |
| SCHEMBL7086266 | 0.79 | ALDH1A1 (0.59) | LSSNPC1RAB9ATSHRALDH1A1 | |
| SCHEMBL6945244 | 0.79 | LSS (0.70) | LSSNPC1RAB9ATSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL19857662 | 0.79 | MAPT (0.67) | TSHRHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925286-B1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ASTRAZENECA AB (SE) | 2003-01-02 | — | — | EP | disclosed |
| US-6093718-A | AN OXIDO-SQUALENE CYCLASE INHIBITOR, ANTICHOLESTEROL AGENT FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND LOWERING CHOLESTEROL LEVELS IN BLOOD PLASMA; TREATING HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2000-07-25 | — | — | US | disclosed |
| EP-0925286-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1999-06-30 | — | — | EP | disclosed |
| WO-1998006705-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1998-02-19 | — | — | WO | disclosed |