Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.52 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.37 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.37 |
| ▸ | MMP2 | P08253 | 6/20 | 0.36 |
| ▸ | MMP3 | P08254 | 6/20 | 0.36 |
| ▸ | MMP7 | P09237 | 5/20 | 0.36 |
| ▸ | MMP1 | P03956 | 5/20 | 0.36 |
| ▸ | CTSC | P53634 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 2/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943060 | 0.93 | ADAM17 (0.61) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL6943542 | 0.91 | ADAM17 (0.52) | ADAM17GRIK1GRIK2MMP2MMP3 | |
| SCHEMBL6942467 | 0.87 | ADAM17 (0.49) | ADAM17GRIK1GRIK2MMP2MMP3 | |
| SCHEMBL6943700 | 0.84 | ADAM17 (0.60) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL6942910 | 0.81 | ADAM17 (0.43) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL6943184 | 0.81 | ADAM17 (0.66) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL6985700 | 0.78 | ADAM17 (0.62) | ADAM17GRIK1GRIK2MMP2MMP3 | |
| SCHEMBL6945913 | 0.76 | ADAM17 (0.63) | ADAM17GRIK1GRIK2MMP2MMP3 | |
| SCHEMBL6939982 | 0.76 | ADAM17 (0.59) | ADAM17GRIK1GRIK2MMP2MMP3 | |
| SCHEMBL6687619 | 0.74 | ADAM17 (0.65) | ADAM17GRIK1GRIK2MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |