Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.63 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.39 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | CTSC | P53634 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 5/20 | 0.35 |
| ▸ | MMP9 | P14780 | 2/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | ANPEP | P15144 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 4/20 | 0.35 |
| ▸ | MMP7 | P09237 | 3/20 | 0.35 |
| ▸ | MMP1 | P03956 | 3/20 | 0.34 |
| ▸ | MMP8 | P22894 | 2/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | MMP14 | P50281 | 1/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943944 | 0.93 | ADAM17 (0.73) | ADAM17MMP2MMP9LTA4HANPEP | |
| SCHEMBL6939982 | 0.88 | ADAM17 (0.59) | ADAM17GRIK1GRIK2HTR2ACTSC | |
| SCHEMBL6944663 | 0.87 | ADAM17 (0.56) | ADAM17GRIK1GRIK2HTR2ACTSC | |
| SCHEMBL7931029 | 0.87 | ADAM17 (0.57) | ADAM17GRIK1GRIK2HTR2ACTSC | |
| SCHEMBL6981671 | 0.85 | ADAM17 (0.69) | ADAM17MMP2MMP9LTA4HANPEP | |
| SCHEMBL6983457 | 0.85 | ADAM17 (0.69) | ADAM17MMP2MMP9LTA4HANPEP | |
| SCHEMBL6981622 | 0.85 | ADAM17 (0.68) | ADAM17GRIK1GRIK2HTR2ACTSC | |
| SCHEMBL7930987 | 0.84 | ADAM17 (0.55) | ADAM17GRIK1GRIK2HTR2ACTSC | |
| SCHEMBL6942575 | 0.84 | ADAM17 (0.73) | ADAM17MMP2MMP9LTA4HANPEP | |
| SCHEMBL6942562 | 0.84 | ADAM17 (0.73) | ADAM17MMP2MMP9LTA4HANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |