Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.42 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.42 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6949620 | 0.85 | CACNA1C (0.55) | TSHRCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL6949624 | 0.84 | KDM4E (0.47) | GAAKDM4EALDH1A1GLAHPGD | |
| SCHEMBL6945806 | 0.83 | CACNA1C (0.59) | TSHRCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL6947692 | 0.82 | KDM4E (0.43) | GAAKDM4EALDH1A1GLAHPGD | |
| SCHEMBL6949149 | 0.81 | PYGM (0.51) | GAAKDM4EALDH1A1GLAHPGD | |
| SCHEMBL6945802 | 0.80 | CACNA1C (0.64) | GAAKDM4EALDH1A1HPGDTSHR | |
| SCHEMBL6952272 | 0.78 | KDM4E (0.41) | GAAKDM4EALDH1A1GLAHPGD | |
| SCHEMBL6953226 | 0.77 | CACNA1C (0.57) | TSHRCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL16178021 | 0.76 | TSHR (0.47) | GAAKDM4EALDH1A1GLAHPGD | |
| SCHEMBL6953550 | 0.75 | CACNA1F (0.50) | KDM4ECACNA1FCACNA1DCACNA1SCACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657432-B1 | Phenyl-substituted 1,4-dihydropyridines with cerebral activity | BAYER AG (DE) | 2003-03-12 | — | — | EP | claimed |
| EP-0657432-B1 | Phenyl-substituted 1,4-dihydropyridines with cerebral activity | BAYER AG (DE) | 2003-03-12 | — | — | EP | disclosed |
| EP-0657432-A1 | Phenyl-substituted 1,4-dihydropyridines with cerebral activity | BAYER AG (DE) | 1995-06-14 | — | — | EP | disclosed |