Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 14/20 | 0.52 |
| ▸ | PTPRC | P08575 | 4/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 4/20 | 0.39 |
| ▸ | PTPRB | P23467 | 4/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | GRB2 | P62993 | 1/20 | 0.34 |
| ▸ | CDC25A | P30304 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7884519 | 0.89 | PTPN1 (0.46) | PTPN1PTPRCPTPN2PTPN6PTPRB | |
| SCHEMBL6951422 | 0.88 | PTPN1 (0.48) | PTPN1PTPRCPTPN2PTPN6ALDH1A1 | |
| SCHEMBL6946520 | 0.86 | PTPN1 (0.69) | PTPN1PTPRCPTPN2PTPN6PTPRB | |
| SCHEMBL7886902 | 0.84 | PTPN1 (0.43) | PTPN1PTPRCPTPN2PTPN6ALDH1A1 | |
| SCHEMBL7879135 | 0.79 | PTPN1 (0.43) | PTPN1PTPRCALDH1A1 | |
| SCHEMBL6944073 | 0.78 | PTPN1 (0.67) | PTPN1PTPRCPTPN2PTPN6PTPRB | |
| SCHEMBL6948682 | 0.78 | PTPN1 (0.63) | PTPN1PTPRCPTPN2GRB2 | |
| SCHEMBL6941175 | 0.77 | PTPN1 (0.59) | PTPN1PTPRCPTPN2PTPN6PTPRB | |
| SCHEMBL7888188 | 0.76 | PTPN1 (0.40) | PTPN1PTPRCPTPRBALDH1A1 | |
| SCHEMBL6941229 | 0.76 | PTPN1 (0.41) | PTPN1PTPRCPTPN2PTPN6PTPRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115729-B1 | PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PTP-1B | MERCK FROSST CANADA INC (CA) | 2003-02-19 | — | — | EP | disclosed |