Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 17/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 5/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 5/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 4/20 | 0.39 |
| ▸ | PGK1 | P00558 | 2/20 | 0.39 |
| ▸ | PGK2 | P07205 | 2/20 | 0.39 |
| ▸ | PTPRC | P08575 | 4/20 | 0.38 |
| ▸ | PTPRB | P23467 | 3/20 | 0.38 |
| ▸ | CDC25A | P30304 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6941175 | 0.82 | PTPN1 (0.59) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| SCHEMBL7840352 | 0.81 | PTPN1 (0.43) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| SCHEMBL6943956 | 0.79 | PTPN1 (0.39) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| SCHEMBL7886828 | 0.79 | PTPN1 (0.55) | PTPN1PTPRC | |
| SCHEMBL6944220 | 0.79 | PGK1 (0.62) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| SCHEMBL6946462 | 0.77 | PTPN1 (0.73) | PTPN1PTPN2PTPRCPTPRB | |
| SCHEMBL7592325 | 0.76 | PTPN1 (0.50) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| SCHEMBL7886821 | 0.76 | PTPN1 (0.70) | PTPN1PTPN2PTPRC | |
| SCHEMBL6946475 | 0.76 | PTPN1 (0.52) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| SCHEMBL6946050 | 0.76 | PTPN1 (0.52) | PTPN1PTPN2PTPN6PTPN11PTPRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115729-B1 | PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PTP-1B | MERCK FROSST CANADA INC (CA) | 2003-02-19 | — | — | EP | disclosed |
| EP-1115729-A1 | PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PTP-1B | Merck Frosst Canada & Co. (CA) | 2001-07-18 | — | — | EP | disclosed |
| US-6174874-B1 | ANTIDIABETIC,-CARCINOGENIC AGENTS; IMPROVING GLUCOSE TOLERANCE/INSULIN-SENSITIVITY; PREVENTING/TREATING OBESITY AND NEURODEGENERATIVE DISEASES; E.G. 1,3-BIS-((PHOSPHONODI-FLUOROMETHYL)PHENYL)-2-DICARBOXYPROPANE | MERCK FROSST CANADA & CO. (CA) | 2001-01-16 | — | — | US | disclosed |
| WO-2000017211-A1 | PHOSPHONIC ACIDS DERIVATIVES AS INHIBITORS OF PTP-1B | MERCK FROSST CANADA & CO. (CA) | 2000-03-30 | — | — | WO | disclosed |