Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 1/20 | 0.40 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.40 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | MPI | P34949 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8917725 | 0.89 | AVPR2 (0.39) | AVPR2AVPR1AAVPR1BMAPTLMNA | |
| SCHEMBL7468044 | 0.89 | SLC6A2 (0.44) | MAPTLMNAALDH1A1POLBSLC6A4 | |
| Hydrochloric Acid SCHEMBL1673605 | 0.88 | SLC6A2 (0.43) | SLC6A4 | |
| Bromide SCHEMBL7864959 | 0.85 | DRD2 (0.47) | AVPR2AVPR1AAVPR1BMAPTSLC6A4 | |
| SCHEMBL22871575 | 0.85 | CHRNB2 (0.47) | AVPR2AVPR1AAVPR1BMAPTLMNA | |
| SCHEMBL14573110 | 0.84 | SLC6A2 (0.40) | SLC6A4DRD2 | |
| Hydrochloric Acid SCHEMBL28259402 | 0.83 | CHRNB2 (0.46) | AVPR2AVPR1AAVPR1BMAPTLMNA | |
| SCHEMBL12326472 | 0.79 | CYP2A6 (0.41) | MAPTSLC6A4DRD2TP53CA2 | |
| SCHEMBL1673484 | 0.77 | MEN1 (0.51) | ALDH1A1RAB9A | |
| SCHEMBL1673540 | 0.76 | MAPT (0.42) | AVPR2AVPR1AAVPR1BMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica N.V. (BE) | 2012-02-29 | — | — | EP | claimed |
| WO-2010124086-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | claimed |