Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6940483 | 0.99 | POLB (0.52) | POLBKMT2AALDH1A1HSP90AA1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6941921 | 0.91 | POLB (0.54) | POLBKMT2AALDH1A1HSP90AA1SMN1; SMN2 | |
| SCHEMBL6943691 | 0.90 | POLB (0.52) | POLBKMT2AALDH1A1HSP90AA1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6938954 | 0.87 | ALDH1A1 (0.45) | POLBKMT2AALDH1A1HSP90AA1SMN1; SMN2 | |
| SCHEMBL6939441 | 0.85 | ALDH1A1 (0.43) | POLBKMT2AALDH1A1HSP90AA1HTT | |
| Hydrochloric Acid SCHEMBL7632203 | 0.83 | CYP1A2 (0.39) | POLBKMT2AALDH1A1PKMHTT | |
| Hydrochloric Acid SCHEMBL6943412 | 0.82 | POLB (0.47) | POLBKMT2AALDH1A1HSP90AA1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6941349 | 0.82 | POLB (0.47) | POLBKMT2AALDH1A1HSP90AA1SMN1; SMN2 | |
| SCHEMBL7805138 | 0.81 | CYP1A2 (0.40) | POLBKMT2AALDH1A1PKMHTT | |
| Hydrochloric Acid SCHEMBL6943586 | 0.81 | HSP90AA1 (0.55) | POLBKMT2AALDH1A1HSP90AA1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066022-B1 | COMPOSITIONS FOR OXIDATION DYEING KERATIN FIBRES COMPRISING A CATIONIC COUPLER, NOVEL CATIONIC COUPLERS, THEIR USE FOR OXIDATION DYEING AND DYEING METHODS | OREAL (FR) | 2003-10-22 | — | — | EP | claimed |
| US-6544298-B1 | Dyeing human hair using coupler | L'OREAL (FR) | 2003-04-08 | — | — | US | claimed |
| US-6537329-B1 | Intense colorations with a wide range of colours, excellent colorfastness | L'OREAL S.A. (FR) | 2003-03-25 | — | — | US | claimed |
| US-6544298-B1 | Dyeing human hair using coupler | L'OREAL (FR) | 2003-04-08 | — | — | US | disclosed |
| US-6537329-B1 | Intense colorations with a wide range of colours, excellent colorfastness | L'OREAL S.A. (FR) | 2003-03-25 | — | — | US | disclosed |