⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9068959 | 1.00 | — | — | |
| SCHEMBL9749195 | 1.00 | — | — | |
| SCHEMBL7138891 | 0.79 | — | — | |
| SCHEMBL15652934 | 0.77 | — | — | |
| SCHEMBL342980 | 0.77 | — | — | |
| SCHEMBL27891874 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL10781424 | 0.75 | ALDH1A1 (0.48) | — | |
| SCHEMBL9631958 | 0.73 | ALDH1A1 (0.46) | — | |
| SCHEMBL7411053 | 0.73 | ALDH1A1 (0.36) | — | |
| SCHEMBL7411792 | 0.73 | ALDH1A1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115873908-A | Method for generating captopril intermediate D-beta-acetylthioisobutyric acid through catalytic hydrolysis | 金达威生物技术(江苏)有限公司 | 2023-03-31 | — | — | CN | disclosed |
| EP-0802182-B1 | PROCESS FOR PRODUCING N-(D-alpha-METHYL-beta-MERCAPTOPROPIONYL)-L-PROLINE AND INTERMEDIATES THEREOF | KANEKA CORP (JP) | 2003-08-27 | — | — | EP | disclosed |
| EP-0889031-B1 | SIMPLE PROCESS FOR PRODUCING HIGH-QUALITY CAPTOPRIL | KANEKA CORP (JP) | 2003-01-15 | — | — | EP | disclosed |
| US-6187932-B1 | SUBJECTING N-(D-ALPHA-METHYL-BETA-ACYLTHIOPROPIONYL)-L-PROLINE TO HYDROLYSIS REACTION IN AQUEOUS MEDIUM IN PRESENCE OF STRONG ACID AT SPECIFIED TEMPERATURE TO REMOVE ACYL GROUP, ISOLATING CAPTOPRIL | KANEKA CORPORATION (JP) | 2001-02-13 | — | — | US | disclosed |
| US-5917055-A | CAPTOPRIL | KANEKA CORPORATION (JP) | 1999-06-29 | — | — | US | disclosed |
| EP-0889031-A1 | SIMPLE PROCESS FOR PRODUCING HIGH-QUALITY CAPTOPRIL | KANEKA CORPORATION (JP) | 1999-01-07 | — | — | EP | disclosed |
| EP-0802182-A1 | PROCESS FOR PRODUCING N-(D-$g(a)-METHYL-$g(b)-MERCAPTOPROPIONYL)-L-PROLINE AND INTERMEDIATES THEREOF | KANEKA CORPORATION (JP) | 1997-10-22 | — | — | EP | disclosed |
| US-5496805-A | DIURETIC, HYPOTENSIVE | E. R. SQUIBB & SONS, INC. (US) | 1996-03-05 | — | — | US | disclosed |
| US-5473081-A | Reacting proline with acylthiopropionic acid halide, deacylating product | MITSUBISHI RAYON CO., LTD. (JP) | 1995-12-05 | — | — | US | disclosed |
| US-5387697-A | Process for the preparation of 1-[3-acetylthio-2(s)-methylpropanoyl]-l-proline | MERCK & CO., INC. (US) | 1995-02-07 | — | — | US | disclosed |
| US-4173704-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1979-11-06 | — | — | US | disclosed |
| US-4156084-A | Certain dimers of tetrahydropyridine-2-carboxylic acids or pyrroline-2-carboxylic acids and derivatives thereof | E. R. SQUIBB & SONS, INC. (US) | 1979-05-22 | — | — | US | disclosed |
| US-4154942-A | Certain tetrahydropyridine-2-carboxylic acids and pyrroline-2-carboxylic acids and derivatives thereof | E. R. SQUIBB & SONS, INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4154840-A | Antihypertensive pipecolic acid derivatives | E. R. SQUIBB & SONS, INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4140797-A | MERCAPTOACYL AMINO ACIDS, ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1979-02-20 | — | — | US | disclosed |
| US-4140786-A | ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1979-02-20 | — | — | US | disclosed |
| US-4129566-A | Derivatives of dehydrocyclicimino acids | E. R. SQUIBB & SONS, INC. (US) | 1978-12-12 | — | — | US | disclosed |
| US-4112119-A | MERCAPTOACYL AMINOACIDS | E. R. SQUIBB & SONS, INC. (US) | 1978-09-05 | — | — | US | disclosed |
| US-4105776-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS, HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1978-08-08 | — | — | US | disclosed |
| US-4053651-A | MERCAPTOACYL AMINO ACIDS, ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1977-10-11 | — | — | US | disclosed |