Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.34 |
| ▸ | DHODH | Q02127 | 2/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6950177 | 0.87 | MAPT (0.43) | MAPTBRD4CREBBPHDAC6HDAC1 | |
| SCHEMBL6945348 | 0.86 | DHODH (0.42) | BRD4CREBBPHDAC6DHODHNPC1 | |
| SCHEMBL6946502 | 0.83 | MAPT (0.44) | MAPTBRD4CREBBPHDAC6HDAC1 | |
| SCHEMBL6951793 | 0.83 | MAPT (0.38) | MAPTBRD4CREBBPHDAC6HDAC1 | |
| SCHEMBL6947548 | 0.82 | MAPT (0.43) | MAPTBRD4CREBBPHDAC6HDAC1 | |
| SCHEMBL6952472 | 0.81 | HDAC1 (0.40) | MAPTHDAC6HDAC1RAB9A | |
| SCHEMBL6949839 | 0.80 | CHEK1 (0.50) | MAPTBRD4CREBBPHDAC6HDAC1 | |
| SCHEMBL6948273 | 0.75 | DHODH (0.51) | MAPTBRD4CREBBPHDAC6HDAC1 | |
| SCHEMBL6945300 | 0.73 | CHEK1 (0.48) | MAPTBRD4CREBBPHDAC6HDAC1 | |
| SCHEMBL6950181 | 0.72 | MAPT (0.43) | MAPTHDAC6HDAC1HSD17B10NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0936218-B1 | BENZIMIDAZOLE DERIVATIVES | MOCHIDA PHARM CO LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| US-6387938-B1 | Benzimidazole derivatives | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-05-14 | — | — | US | disclosed |
| EP-0936218-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1999-08-18 | — | — | EP | disclosed |