Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 11/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | BRS3 | P32247 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947173 | 0.86 | MAPT (0.39) | DHODHHDAC6NPC1RAB9ABRD4 | |
| SCHEMBL6951783 | 0.85 | DHODH (0.47) | DHODHHDAC6RNASEH1NPC1RAB9A | |
| SCHEMBL6952472 | 0.80 | HDAC1 (0.40) | HDAC6RAB9A | |
| SCHEMBL6951793 | 0.79 | MAPT (0.38) | HDAC6NPC1RAB9ABRD4CREBBP | |
| SCHEMBL6950048 | 0.77 | RNASEH1 (0.50) | DHODHHDAC6RNASEH1NPC1RAB9A | |
| SCHEMBL6948937 | 0.76 | DHODH (0.58) | DHODHHDAC6RNASEH1NPC1RAB9A | |
| SCHEMBL6948954 | 0.73 | NPC1 (0.55) | DHODHHDAC6RNASEH1NPC1RAB9A | |
| SCHEMBL6950177 | 0.71 | MAPT (0.43) | HDAC6NPC1RAB9ABRD4CREBBP | |
| SCHEMBL6950091 | 0.69 | DHODH (0.69) | DHODHHDAC6BRS3 | |
| SCHEMBL6945364 | 0.69 | RAB9A (0.52) | DHODHHDAC6RNASEH1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0936218-B1 | BENZIMIDAZOLE DERIVATIVES | MOCHIDA PHARM CO LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| US-6387938-B1 | Benzimidazole derivatives | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-05-14 | — | — | US | disclosed |
| EP-0936218-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1999-08-18 | — | — | EP | disclosed |