Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 6/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | PARP1 | P09874 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6949839 | 0.92 | CHEK1 (0.50) | HDAC3PARP1HDAC4HDAC1HDAC7 | |
| SCHEMBL6948956 | 0.89 | DHODH (0.54) | DHODHPRMT5NR1H4HDAC3PARP1 | |
| SCHEMBL6945300 | 0.88 | CHEK1 (0.48) | HDAC3PARP1HDAC4HDAC1HDAC7 | |
| SCHEMBL6948278 | 0.85 | PRMT5 (0.45) | DHODHPRMT5NR1H4MAPTGABRA1 | |
| SCHEMBL6950091 | 0.84 | DHODH (0.69) | DHODHHDAC3PARP1HDAC4HDAC1 | |
| SCHEMBL6948942 | 0.82 | BRD4 (0.50) | DHODHPARP1HDAC6MAPTALDH1A1 | |
| SCHEMBL6946502 | 0.81 | MAPT (0.44) | DHODHHDAC1HDAC6CHEK1MAPT | |
| SCHEMBL6950177 | 0.79 | MAPT (0.43) | HDAC1HDAC6CHEK1MAPTL3MBTL1 | |
| SCHEMBL6942886 | 0.79 | PARP1 (0.48) | PARP1CHEK1MAPTBRD4CREBBP | |
| SCHEMBL6946441 | 0.79 | PARP1 (0.48) | DHODHPARP1HDAC6BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0936218-B1 | BENZIMIDAZOLE DERIVATIVES | MOCHIDA PHARM CO LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| US-6387938-B1 | Benzimidazole derivatives | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-05-14 | — | — | US | disclosed |
| EP-0936218-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1999-08-18 | — | — | EP | disclosed |