Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.33 |
| ▸ | UGT2B17 | O75795 | 2/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL326748 | 0.89 | CYP11B1 (0.38) | EPAS1CYP11B1CYP11B2 | |
| SCHEMBL13612885 | 0.82 | UGT2B17 (0.31) | HTR6UGT2B17CYP11B1CYP11B2 | |
| SCHEMBL31127749 | 0.82 | EPAS1 (0.32) | UGT2B17EPAS1 | |
| SCHEMBL27982324 | 0.74 | HTR6 (0.33) | HTR6 | |
| SCHEMBL29197997 | 0.74 | — | — | |
| SCHEMBL30858742 | 0.72 | HTR6 (0.36) | HTR6RAB9A | |
| SCHEMBL24593689 | 0.70 | UGT2B17 (0.51) | UGT2B17EPAS1CYP11B1CYP11B2 | |
| SCHEMBL6958845 | 0.70 | UGT2B17 (0.51) | UGT2B17EPAS1CYP11B1CYP11B2 | |
| SCHEMBL16800617 | 0.70 | CYP11B1 (0.37) | CYP11B1CYP11B2 | |
| SCHEMBL13882545 | 0.70 | PGR (0.45) | HTR6UGT2B17CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757677-B1 | BENZOCYCLOHEXYLIMIDAZOLETHIONE DERIVATIVES | SYNTEX LLC (US) | 2003-06-18 | — | — | EP | disclosed |
| US-5719280-A | REACTING AMINE SUBSTITUTED BENZOCYCLOALKANE WITH DIALKYLOXYACETALDEHYDE IN PRESENCE OF REDUCING AGENT OR CATALYTIC HYDROGENATION, TREATING WITH THIOCYANIC ACID | SYNTEX (U.S.A.) INC. (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0757677-A1 | BENZOCYCLOALKYLAZOLETHIONE DERIVATIVES | SYNTEX (U.S.A.) INC. (US) | 1997-02-12 | — | — | EP | disclosed |
| US-5538988-A | CARDIOVASCULAR DISORDERS AND DOPAMINE HYDROLASE ENZYME INHIBITORS | SYNTEX (U.S.A.) INC. | 1996-07-23 | — | — | US | disclosed |
| WO-1995029165-A2 | BENZOCYCLOALKYLAZ0LETHIONE DERIVATIVES AS DOPAMIN BETA-HYDROXYLASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1995-11-02 | — | — | WO | disclosed |