Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.53 |
| ▸ | TUBB | P07437 | 1/20 | 0.53 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.53 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.53 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.53 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.53 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.53 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.53 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.53 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.53 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.53 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.53 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1337032 | 1.00 | ACHE (0.56) | ACHECYP3A4MAPTCA9TUBB1 | |
| SCHEMBL429756 | 0.97 | ACHE (0.59) | ACHECYP3A4MAPTCA9TUBB1 | |
| SCHEMBL11933625 | 0.83 | ACHE (0.50) | ACHECYP3A4MAPTCA9TUBB1 | |
| SCHEMBL9376185 | 0.83 | TUBB1 (0.50) | ACHECYP3A4MAPTCA9TUBB1 | |
| SCHEMBL30927163 | 0.81 | ALOX15 (0.56) | ACHECYP3A4MAPTCA9TUBB1 | |
| SCHEMBL20523468 | 0.81 | POLB (0.48) | ACHECYP3A4MAPTCA9TUBB1 | |
| SCHEMBL30874274 | 0.81 | POLB (0.48) | ACHECYP3A4MAPTCA9TUBB1 | |
| SCHEMBL129971 | 0.81 | ALOX15 (0.56) | ACHECYP3A4MAPTCA9TUBB1 | |
| SCHEMBL31500460 | 0.81 | ALOX15 (0.47) | ACHECYP3A4MAPTCA9TUBB1 | |
| SCHEMBL26927713 | 0.81 | ALOX15 (0.47) | ACHECYP3A4MAPTCA9TUBB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1121338-A4 | METHOD FOR SYNTHESIZING DIARYL-SUBSTITUTED HETEROCYCLIC COMPOUNDS, INCLUDING TETRAHYDROFURANS | MILLENNIUM PHARM INC (US) | 2003-03-12 | — | — | EP | disclosed |
| EP-1121338-A1 | METHOD FOR SYNTHESIZING DIARYL-SUBSTITUTED HETEROCYCLIC COMPOUNDS, INCLUDING TETRAHYDROFURANS | Millennium Pharmaceuticals, Inc. (US) | 2001-08-08 | — | — | EP | disclosed |
| WO-2000023409-A1 | METHOD FOR SYNTHESIZING DIARYL-SUBSTITUTED HETEROCYCLIC COMPOUNDS, INCLUDING TETRAHYDROFURANS | LEUKOSITE, INC. (US) | 2000-04-27 | — | — | WO | disclosed |