Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6402719 | 0.78 | NPC1 (0.53) | NPC1RAB9AKDM4CMEN1KMT2A | |
| SCHEMBL6400712 | 0.78 | NPC1 (0.59) | NPC1RAB9AKDM4CMEN1KMT2A | |
| SCHEMBL6408281 | 0.76 | NPC1 (0.44) | NPC1RAB9AKDM4CMEN1KMT2A | |
| SCHEMBL13528874 | 0.72 | NPC1 (0.54) | NPC1RAB9AKDM4CMEN1KMT2A | |
| SCHEMBL30076909 | 0.71 | L3MBTL1 (0.52) | NPC1RAB9AKDM4CMEN1KMT2A | |
| SCHEMBL7217804 | 0.70 | NPC1 (0.43) | NPC1RAB9AMEN1KMT2AOPRM1 | |
| SCHEMBL8580077 | 0.70 | L3MBTL1 (0.59) | NPC1RAB9AKDM4CMEN1KMT2A | |
| SCHEMBL6402015 | 0.70 | NPC1 (0.45) | NPC1RAB9AKDM4CMEN1KMT2A | |
| SCHEMBL5610112 | 0.70 | NPC1 (0.48) | NPC1RAB9AKDM4CMEN1KMT2A | |
| SCHEMBL19127703 | 0.69 | NPC1 (0.51) | NPC1RAB9AKDM4CMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178984-B1 | 1-TRIFLUOROMETHYL-4-HYDROXY-7-PIPERIDINYL-AMINOMETHYLCHROMAN DERIVATIVES | PFIZER PROD INC (US) | 2003-03-19 | — | — | EP | disclosed |