Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7212889 | 0.85 | KDM4E (0.33) | NPC1RAB9ATSHRKDM4EALDH1A1 | |
| SCHEMBL7211776 | 0.82 | KDM4C (0.36) | NPC1RAB9AHTR2AMEN1KMT2A | |
| SCHEMBL9123646 | 0.76 | DHFR (0.35) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL9119549 | 0.76 | DHFR (0.31) | — | |
| SCHEMBL2014844 | 0.75 | ALDH1A1 (0.36) | MEN1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL7050550 | 0.72 | SIGMAR1 (0.39) | MEN1KMT2A | |
| SCHEMBL6400656 | 0.72 | NPC1 (0.50) | NPC1RAB9AMEN1KMT2A | |
| SCHEMBL17145065 | 0.72 | DPP4 (0.41) | HTR2A | |
| SCHEMBL16543024 | 0.71 | NPC1 (0.41) | NPC1RAB9ATSHRALDH1A1GAA | |
| SCHEMBL6253588 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178960-B1 | VITAMIN D ANALOGUES AND THEIR PHARMACEUTICAL USE | LEO PHARMA AS (DK) | 2003-11-05 | — | — | EP | disclosed |
| EP-1178960-A1 | VITAMIN D ANALOGUES AND THEIR PHARMACEUTICAL USE | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000064869-A1 | VITAMIN D ANALOGUES AND THEIR PHARMACEUTICAL USE | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 2000-11-02 | — | — | WO | disclosed |