SCHEMBL6947487

SCHEMBL6947487

O=Cc1c(Cl)ccc2occc12

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.43
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
TDP1 Q9NUW8 1/20 0.43
CYP2A6 P11509 1/20 0.39
MAOA P21397 3/20 0.38
MAOB P27338 3/20 0.38
FTO Q9C0B1 2/20 0.38
NFKB1 P19838 1/20 0.37
PTPN1 P18031 3/20 0.37
PAX8 Q06710 1/20 0.34
ACHE P22303 1/20 0.33
DYRK1A Q13627 1/20 0.32
HTR2A P28223 1/20 0.32
HTR2C P28335 1/20 0.32
HTR2B P41595 1/20 0.32
ADORA3 P0DMS8 1/20 0.31
KDM4E B2RXH2 1/20 0.30
CYP3A4 P08684 1/20 0.30
HPGD P15428 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29951410 0.77 ERN1 (0.47) ALDH1A1MEN1KMT2ACYP2A6MAOA
SCHEMBL6957213 0.77 CYP2A6 (0.39) ALDH1A1MEN1KMT2ACYP2A6MAOA
SCHEMBL6194067 0.77 ERN1 (0.47) ALDH1A1MEN1KMT2ACYP2A6MAOA
SCHEMBL6949118 0.74 CYP2A6 (0.31) CYP2A6MAOAMAOBFTO
SCHEMBL6949125 0.74 CYP2A6 (0.31) CYP2A6MAOAMAOBFTO
SCHEMBL8800450 0.73 MAOA (0.38) ALDH1A1MEN1KMT2ACYP2A6MAOA
SCHEMBL6637551 0.73 HTR2A (0.43) ALDH1A1MEN1KMT2ACYP2A6MAOA
SCHEMBL8799124 0.73 MAOA (0.40) ALDH1A1MEN1KMT2ACYP2A6MAOA
SCHEMBL30600426 0.71 ALDH1A1 (0.68) ALDH1A1MEN1KMT2ATDP1CYP2A6
SCHEMBL6921642 0.69 MAOA (0.38) MAOAMAOBFTONFKB1PAX8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0901483-B1 BENZOFURANS AND BENZOPYRANS AS CHRONOBIOLOGICAL AGENTS GLAXO GROUP LTD (GB) 2003-07-09 EP disclosed
US-5981572-A Benzofurans and benzopyrans as chronobiological agents GLAXO WELLCOME INC. (US) 1999-11-09 US disclosed
EP-0901483-A2 BENZOFURANS AND BENZOPYRANS AS CHRONOBIOLOGICAL AGENTS GLAXO GROUP LIMITED (GB) 1999-03-17 EP disclosed
WO-1997043272-A2 BENZOFURANS AND BENZOPYRANS AS CHRONOBIOLOGICAL AGENTS GLAXO GROUP LIMITED (GB) 1997-11-20 WO disclosed