SCHEMBL6947622

SCHEMBL6947622

COC(=O)CCn1nnnc1CC[C@H](N)C(=O)O

nearest known ligand 0.45

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
NAALAD2 Q9Y3Q0 2/20 0.45
SLC1A1 P43005 1/20 0.42
GHSR Q92847 3/20 0.40
TRPV1 Q8NER1 1/20 0.38
GRIA4 P48058 4/20 0.37
GRIA1 P42261 3/20 0.37
GRIA2 P42262 3/20 0.37
GRIA3 P42263 3/20 0.37
TP53 P04637 1/20 0.34
GAA P10253 1/20 0.34
MAPT P10636 1/20 0.34
KMT2A Q03164 1/20 0.33
NPC1 O15118 1/20 0.32
ALDH1A1 P00352 1/20 0.32
RAB9A P51151 1/20 0.32
HSD11B1 P28845 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6948521 0.87 TRPV1 (0.49) NAALAD2SLC1A1TRPV1GRIA4GRIA1
SCHEMBL30945382 0.77 NAALAD2 (0.68) NAALAD2GHSRGRIA4GRIA1GRIA2
Chloromethane SCHEMBL29231841 0.77 NAALAD2 (0.64) NAALAD2GHSRGRIA4GRIA1GRIA2
Hydrochloric Acid SCHEMBL21494707 0.76 NAALAD2 (0.67) NAALAD2GHSRGRIA4GRIA1GRIA2
Hydrochloric Acid SCHEMBL21494705 0.76 NAALAD2 (0.67) NAALAD2GHSRGRIA4GRIA1GRIA2
SCHEMBL6954225 0.75 NAALAD2 (0.39) NAALAD2TRPV1GRIA4GRIA1GRIA2
SCHEMBL23030236 0.73 NAALAD2 (0.46) NAALAD2TRPV1NPC1ALDH1A1RAB9A
SCHEMBL21515089 0.73 NAALAD2 (0.60) NAALAD2GHSRTRPV1
SCHEMBL28504133 0.73 NAALAD2 (0.60) NAALAD2GHSRTRPV1
Hydrochloric Acid SCHEMBL21494731 0.72 NAALAD2 (0.58) NAALAD2GHSR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0758328-B1 ANTI-CANCER COMPOUNDS CONTAINING CYCLOPENTAQUINAZOLINE RING BTG INT LTD (GB) 2003-07-16 EP disclosed
EP-0758328-A1 ANTI-CANCER COMPOUNDS CONTAINING CYCLOPENTAQUINAZOLINE RING BTG INTERNATIONAL LIMITED (GB) 1997-02-19 EP disclosed
WO-1995030673-A1 ANTI-CANCER COMPOUNDS CONTAINING CYCLOPENTAQUINAZOLINE RING BRITISH TECHNOLOGY GROUP LIMITED (GB) 1995-11-16 WO disclosed