Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 2/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD5 | P21918 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29339100 | 0.82 | HRH3 (0.33) | NOS1HRH3NCF1MAOAMAOB | |
| SCHEMBL12972268 | 0.78 | HRH3 (0.36) | NOS1HRH3MAOAMAOBDRD2 | |
| SCHEMBL24131684 | 0.76 | HRH3 (0.35) | NOS1HRH3MAOAMAOBDRD2 | |
| SCHEMBL17284674 | 0.76 | MAOA (0.37) | NOS1HRH3NCF1MAOAMAOB | |
| SCHEMBL6947992 | 0.76 | ESR2 (0.36) | NOS1HRH3MAOAMAOBDRD2 | |
| SCHEMBL8351750 | 0.76 | — | — | |
| SCHEMBL29338854 | 0.76 | ABCB1 (0.35) | HRH3NCF1 | |
| SCHEMBL6950619 | 0.76 | GNAI3 (0.39) | DRD2DRD3 | |
| SCHEMBL17282138 | 0.73 | HRH3 (0.33) | HRH3MAOAMAOBDRD2DRD1 | |
| SCHEMBL12374770 | 0.73 | MAOA (0.33) | HRH3MAOAMAOBDRD2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0829474-B1 | INDAZOLE DERIVATIVES HAVING MONOCYCLIC AMINO GROUP | NISSHIN SEIFUN GROUP INC (JP) | 2003-04-09 | — | — | EP | disclosed |
| US-6096746-A | Indazole compound containing a monocyclic amine structure | NISSHIN FLOUR MILLING CO., LTD. (JP) | 2000-08-01 | — | — | US | disclosed |
| US-5945434-A | TREATMENT OF GASTROINTESTINAL DISORDERS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1999-08-31 | — | — | US | disclosed |
| EP-0829474-A1 | INDAZOLE DERIVATIVES HAVING MONOCYCLIC AMINO GROUP | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1998-03-18 | — | — | EP | disclosed |