Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 6/20 | 0.42 |
| ▸ | HRH2 | P25021 | 7/20 | 0.39 |
| ▸ | HRH1 | P35367 | 7/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL524089 | 0.82 | HRH2 (0.55) | POLBSMN1; SMN2LMNACTSKHRH2 | |
| SCHEMBL524090 | 0.82 | HRH2 (0.55) | POLBSMN1; SMN2LMNACTSKHRH2 | |
| SCHEMBL524083 | 0.81 | ALDH1A1 (0.56) | POLBSMN1; SMN2LMNACTSKHRH2 | |
| SCHEMBL523962 | 0.81 | HRH2 (0.52) | POLBSMN1; SMN2LMNACTSKHRH2 | |
| SCHEMBL524045 | 0.80 | HRH2 (0.50) | POLBSMN1; SMN2LMNACTSKHRH2 | |
| SCHEMBL524046 | 0.80 | HRH2 (0.50) | POLBSMN1; SMN2LMNACTSKHRH2 | |
| SCHEMBL522826 | 0.80 | POLB (0.45) | POLBSMN1; SMN2LMNACTSKHRH2 | |
| SCHEMBL522825 | 0.80 | POLB (0.45) | POLBSMN1; SMN2LMNACTSKHRH2 | |
| SCHEMBL524497 | 0.79 | HRH2 (0.57) | POLBSMN1; SMN2LMNACTSKHRH2 | |
| SCHEMBL523727 | 0.79 | CTSK (0.50) | POLBSMN1; SMN2LMNACTSKHRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421859-A1 | THIAZOLE DERIVATIVES AND THEIR USE AS P2Y12 RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010122504-A1 | THIAZOLE DERIVATIVES AND THEIR USE AS P2Y12 RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2010-10-28 | — | — | WO | disclosed |