Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT8 | Q9H7Z6 | 9/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | EP300 | Q09472 | 7/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | FNTA | P49354 | 1/20 | 0.53 |
| ▸ | FNTB | P49356 | 1/20 | 0.53 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.50 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8008711 | 1.00 | KAT8 (0.59) | KAT8KMT2AMEN1EP300GAA | |
| SCHEMBL8423937 | 0.94 | KMT2A (0.54) | KAT8KMT2AMEN1EP300GAA | |
| SCHEMBL8423941 | 0.94 | KMT2A (0.54) | KAT8KMT2AMEN1EP300GAA | |
| SCHEMBL8011329 | 0.90 | GAA (0.65) | KMT2AMEN1GAAAMY1APOLB | |
| SCHEMBL6945888 | 0.90 | GAA (0.65) | KMT2AMEN1GAAAMY1APOLB | |
| SCHEMBL8423943 | 0.88 | GAA (0.47) | KAT8KMT2AMEN1EP300GAA | |
| SCHEMBL6950148 | 0.87 | FNTA (0.56) | KAT8KMT2AMEN1EP300GAA | |
| SCHEMBL6950144 | 0.87 | FNTA (0.56) | KAT8KMT2AMEN1EP300GAA | |
| SCHEMBL6951899 | 0.86 | KAT8 (0.53) | KAT8KMT2AMEN1EP300GAA | |
| SCHEMBL8009118 | 0.86 | KAT8 (0.53) | KAT8KMT2AMEN1EP300GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743304-B1 | 4-(Arylaminomethylene)-2,4-dihydro-pyrazol-3-ones | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |
| US-6034099-A | Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones | CELL PATHWAYS, INC. (US) | 2000-03-07 | — | — | US | disclosed |
| EP-0743304-A1 | 4-(Arylaminomethylene)-2,4-dihydro-pyrazol-3-ones | MERCK PATENT GmbH (DE) | 1996-11-20 | — | — | EP | disclosed |