Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 12/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 8/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 8/20 | 0.56 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6945888 | 1.00 | GAA (0.65) | GAAKMT2AL3MBTL1POLBMEN1 | |
| SCHEMBL6947870 | 0.90 | KAT8 (0.59) | GAAKMT2AL3MBTL1POLBMEN1 | |
| SCHEMBL8008711 | 0.90 | KAT8 (0.59) | GAAKMT2AL3MBTL1POLBMEN1 | |
| SCHEMBL6949451 | 0.85 | GAA (0.50) | GAAKMT2AL3MBTL1POLBMEN1 | |
| SCHEMBL6949454 | 0.85 | GAA (0.50) | GAAKMT2AL3MBTL1POLBMEN1 | |
| SCHEMBL8423941 | 0.85 | KMT2A (0.54) | GAAKMT2AL3MBTL1POLBMEN1 | |
| SCHEMBL8423937 | 0.85 | KMT2A (0.54) | GAAKMT2AL3MBTL1POLBMEN1 | |
| SCHEMBL6947863 | 0.85 | KDM4E (0.57) | GAAKMT2AL3MBTL1POLBMEN1 | |
| SCHEMBL8423943 | 0.84 | GAA (0.47) | GAAKMT2AL3MBTL1POLBMEN1 | |
| SCHEMBL8011684 | 0.84 | GAA (0.47) | GAAKMT2AL3MBTL1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6034099-A | Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones | CELL PATHWAYS, INC. (US) | 2000-03-07 | — | — | US | disclosed |
| EP-0930881-A1 | PYRAZOLINONES TO TREAT DISTURBANCES OF POTENCY | MERCK PATENT GmbH (DE) | 1999-07-28 | — | — | EP | disclosed |
| WO-1998016224-A1 | PYRAZOLINONES TO TREAT DISTURBANCES OF POTENCY | MERCK PATENT GMBH (DE) | 1998-04-23 | — | — | WO | disclosed |