Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 17/20 | 0.61 |
| ▸ | TACR1 | P25103 | 15/20 | 0.61 |
| ▸ | TACR3 | P29371 | 5/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | CCR5 | P51681 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8148884 | 0.93 | TACR2 (0.60) | TACR2TACR1TACR3CYP3A4CYP2D6 | |
| SCHEMBL8148888 | 0.93 | TACR2 (0.60) | TACR2TACR1TACR3CYP3A4CYP2D6 | |
| SCHEMBL8129263 | 0.87 | CHRM2 (0.48) | TACR2TACR1 | |
| SCHEMBL8640738 | 0.85 | TACR2 (0.67) | TACR2TACR1TACR3CYP3A4CYP2D6 | |
| SCHEMBL6954575 | 0.85 | TACR2 (0.67) | TACR2TACR1TACR3CYP3A4CYP2D6 | |
| SCHEMBL7137053 | 0.84 | TACR2 (0.59) | TACR2TACR1TACR3CYP3A4CYP2D6 | |
| SCHEMBL7137046 | 0.84 | TACR2 (0.59) | TACR2TACR1TACR3CYP3A4CYP2D6 | |
| SCHEMBL6951030 | 0.83 | TACR2 (0.63) | TACR2TACR1TACR3CYP3A4CYP2D6 | |
| SCHEMBL7488687 | 0.82 | TACR2 (0.62) | TACR2TACR1TACR3HRH1 | |
| SCHEMBL4943041 | 0.81 | TACR2 (0.48) | TACR2TACR1TACR3CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0871623-B1 | 3-AZETIDINYLALKYLPIPERIDINES OR -PYRROLIDINES AS TACHYKININ ANTAGONISTS | PFIZER RES & DEV (IE) | 2003-02-12 | — | — | EP | disclosed |
| US-6242438-B1 | 3-Azetidinylalkylpiperidines or -pyrrolidines as tachykinin antagonists | PFIZER INC. | 2001-06-05 | — | — | US | disclosed |