Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | MBTD1 | Q05BQ5 | 2/20 | 0.54 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7077522 | 0.88 | GAA (0.61) | ALDH1A1KDM4EGAACASP3MEN1 | |
| SCHEMBL6954598 | 0.87 | GAA (0.63) | ALDH1A1KDM4EGAACASP3MEN1 | |
| SCHEMBL6951357 | 0.83 | GAA (0.60) | ALDH1A1GAAHSD17B10CASP3MEN1 | |
| SCHEMBL7430586 | 0.83 | GAA (0.60) | ALDH1A1KDM4EGAAHPGDCYP2C19 | |
| SCHEMBL6949259 | 0.80 | GAA (0.53) | ALDH1A1GAAMEN1KMT2A | |
| SCHEMBL7442190 | 0.79 | GAA (0.55) | GAACASP3 | |
| SCHEMBL7079432 | 0.78 | GAA (0.54) | ALDH1A1GAAHPGDCASP3MEN1 | |
| SCHEMBL6947705 | 0.78 | GAA (0.62) | ALDH1A1KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL6951287 | 0.78 | GAA (0.58) | ALDH1A1GAAHSD17B10MEN1KMT2A | |
| SCHEMBL8307191 | 0.77 | GAA (0.61) | ALDH1A1KDM4EGAAHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0988035-B1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2003-05-02 | — | — | EP | claimed |
| US-6214858-B1 | PREVENTING AND TREATING EXCESSIVE CELL DEATH USING OXINDOLE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION | 2001-04-10 | — | — | US | claimed |
| EP-0988035-B1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2003-05-02 | — | — | EP | disclosed |
| EP-0988035-A4 | CASPASES AND APOPTOSIS | SMITHKLINE BECKMAN CORP (US) | 2001-09-19 | — | — | EP | disclosed |
| US-6214858-B1 | PREVENTING AND TREATING EXCESSIVE CELL DEATH USING OXINDOLE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION | 2001-04-10 | — | — | US | disclosed |
| EP-0988035-A1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-03-29 | — | — | EP | disclosed |
| WO-1999006042-A1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-11 | — | — | WO | disclosed |