Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 6/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7811627 | 0.94 | TSHR (0.53) | GAASMN1; SMN2TSHRHTTALDH1A1 | |
| SCHEMBL6949259 | 0.84 | GAA (0.53) | GAASMN1; SMN2TSHRHTTALDH1A1 | |
| SCHEMBL7430586 | 0.82 | GAA (0.60) | GAASMN1; SMN2HTTALDH1A1HSD17B10 | |
| SCHEMBL6951357 | 0.82 | GAA (0.60) | GAAALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL6954598 | 0.80 | GAA (0.63) | GAAALDH1A1MEN1KMT2APOLB | |
| SCHEMBL7077522 | 0.79 | GAA (0.61) | GAAALDH1A1MEN1KMT2APOLB | |
| SCHEMBL6948048 | 0.78 | ALDH1A1 (0.57) | GAAALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL31212426 | 0.78 | MEN1 (0.67) | GAASMN1; SMN2TSHRHTTALDH1A1 | |
| SCHEMBL31212433 | 0.78 | MEN1 (0.67) | GAASMN1; SMN2TSHRHTTALDH1A1 | |
| SCHEMBL7442190 | 0.77 | GAA (0.55) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0988035-B1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2003-05-02 | — | — | EP | claimed |
| US-6214858-B1 | PREVENTING AND TREATING EXCESSIVE CELL DEATH USING OXINDOLE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION | 2001-04-10 | — | — | US | claimed |
| EP-0988035-B1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6214858-B1 | PREVENTING AND TREATING EXCESSIVE CELL DEATH USING OXINDOLE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION | 2001-04-10 | — | — | US | disclosed |