Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6810427 | 0.90 | PKN1 (0.58) | TSHRPARP1MAPK1NPSR1PKN1 | |
| SCHEMBL5970052 | 0.88 | TSHR (0.55) | TSHRMAPK1KDM4EHSD17B10TDP1 | |
| SCHEMBL697780 | 0.85 | KDM4E (0.54) | PARP1KDM4ETDP1L3MBTL1ALDH1A1 | |
| SCHEMBL3580405 | 0.85 | MMP2 (0.50) | PARP1MAPK1L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3574926 | 0.83 | MAPT (0.55) | MAPK1L3MBTL1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL10212480 | 0.83 | KDM4E (0.55) | PARP1KDM4ETDP1L3MBTL1ALDH1A1 | |
| SCHEMBL25433684 | 0.83 | SCN1A (0.43) | TSHRPARP1MAPK1KDM4EHSD17B10 | |
| SCHEMBL6170666 | 0.82 | TSHR (0.53) | TSHRPARP1KDM4EHSD17B10L3MBTL1 | |
| SCHEMBL5886053 | 0.82 | TNKS (0.43) | PARP1KDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL3575168 | 0.81 | SIRT2 (0.52) | PARP1HSD17B10TDP1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0936218-B1 | BENZIMIDAZOLE DERIVATIVES | MOCHIDA PHARM CO LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| US-6387938-B1 | Benzimidazole derivatives | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-05-14 | — | — | US | disclosed |
| EP-0936218-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1999-08-18 | — | — | EP | disclosed |