Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 3/20 | 0.50 |
| ▸ | MMP9 | P14780 | 3/20 | 0.50 |
| ▸ | MMP8 | P22894 | 3/20 | 0.50 |
| ▸ | AR | P10275 | 2/20 | 0.50 |
| ▸ | PARP1 | P09874 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | TNKS | O95271 | 2/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.47 |
| ▸ | GUSB | P08236 | 1/20 | 0.47 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.47 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.47 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.47 |
| ▸ | MMP13 | P45452 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3574926 | 0.89 | MAPT (0.55) | MMP2MMP9MMP8RAB9AMAPT | |
| SCHEMBL6948237 | 0.85 | TSHR (0.50) | PARP1RAB9AGAAMAPTMEN1 | |
| SCHEMBL6810427 | 0.83 | PKN1 (0.58) | MMP2PARP1MMP13MAPK1 | |
| SCHEMBL3580402 | 0.83 | PARP1 (0.69) | MMP2MMP9MMP8ARPARP1 | |
| SCHEMBL6330688 | 0.79 | MMP2 (0.62) | MMP2MMP9MMP8PARP1RAB9A | |
| SCHEMBL6170666 | 0.78 | TSHR (0.53) | PARP1GAAMAPTPOLBALDH1A1 | |
| SCHEMBL6804379 | 0.78 | ATM (0.52) | PARP1MAPTMEN1KMT2APOLB | |
| SCHEMBL3575168 | 0.77 | SIRT2 (0.52) | PARP1GAAMAPTTNKSTNKS2 | |
| SCHEMBL3580810 | 0.76 | CHEK1 (0.59) | PARP1RAB9AGAAGUSBPOLB | |
| SCHEMBL3577856 | 0.76 | KDM4E (0.50) | PARP1RAB9AMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |