Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 7/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7505778 | 0.84 | KDM4E (0.47) | ALDH1A1KDM4EHPGDMEN1CYP1A2 | |
| SCHEMBL7553432 | 0.79 | KDM4E (0.44) | ALDH1A1KDM4EHPGDMEN1CYP1A2 | |
| SCHEMBL6951194 | 0.78 | RAB9A (0.44) | ALDH1A1KDM4EHPGDPKMRAB9A | |
| SCHEMBL6949166 | 0.78 | RAB9A (0.43) | ALDH1A1KDM4EHPGDPKMRAB9A | |
| SCHEMBL6951215 | 0.77 | PTGS2 (0.44) | ALDH1A1KDM4EPKMRAB9AMEN1 | |
| SCHEMBL6947058 | 0.76 | PTGS2 (0.42) | ALDH1A1KDM4EHPGDPKMRAB9A | |
| SCHEMBL7502692 | 0.75 | MEN1 (0.46) | ALDH1A1MEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7507179 | 0.74 | KDM4E (0.43) | ALDH1A1KDM4EHPGDPKMRAB9A | |
| SCHEMBL6952960 | 0.74 | PTGS2 (0.46) | ALDH1A1KDM4EHPGDPKMRAB9A | |
| SCHEMBL7502512 | 0.73 | KDM4E (0.43) | ALDH1A1KDM4EHPGDMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0985666-B1 | Substituted indole compounds as COX-2 inhibitors | PFIZER (US) | 2003-11-05 | — | — | EP | claimed |
| US-6277878-B1 | ANTIINFLAMMATORY AGENTS; ANALGESICS | PFIZER INC | 2001-08-21 | — | — | US | claimed |
| EP-0985666-A1 | Substituted indole compounds as COX-2 inhibitors | PFIZER INC. (US) | 2000-03-15 | — | — | EP | claimed |
| EP-0985666-B1 | Substituted indole compounds as COX-2 inhibitors | PFIZER (US) | 2003-11-05 | — | — | EP | disclosed |
| US-6277878-B1 | ANTIINFLAMMATORY AGENTS; ANALGESICS | PFIZER INC | 2001-08-21 | — | — | US | disclosed |
| EP-0985666-A1 | Substituted indole compounds as COX-2 inhibitors | PFIZER INC. (US) | 2000-03-15 | — | — | EP | disclosed |