Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTCH1 | P46531 | 18/20 | 0.40 |
| ▸ | RBPJ | Q06330 | 5/20 | 0.40 |
| ▸ | NOTCH3 | Q9UM47 | 13/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6954233 | 0.88 | NOTCH1 (0.35) | NOTCH1RBPJNOTCH3 | |
| SCHEMBL13502693 | 0.87 | CCKBR (0.42) | NOTCH1RBPJNOTCH3 | |
| SCHEMBL6949634 | 0.87 | NOTCH1 (0.39) | NOTCH1RBPJNOTCH3KMT2A | |
| SCHEMBL3589772 | 0.79 | PSEN1 (0.50) | — | |
| SCHEMBL6948349 | 0.78 | CCKBR (0.39) | NOTCH1RBPJNOTCH3 | |
| SCHEMBL3594079 | 0.76 | PSEN1 (0.40) | NOTCH1RBPJKMT2A | |
| SCHEMBL6952065 | 0.75 | CCKBR (0.34) | NOTCH1NOTCH3KMT2A | |
| SCHEMBL6954236 | 0.75 | CCKAR (0.38) | NOTCH1RBPJNOTCH3 | |
| SCHEMBL6955221 | 0.71 | NOTCH1 (0.49) | NOTCH1RBPJNOTCH3 | |
| SCHEMBL13502688 | 0.69 | PSEN1 (0.46) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268433-A1 | CYCLIC LACTAMS AS INHIBITORS OF A-BETA-PROTEIN PRODUCTION | Bristol-Myers Squibb Pharma Company (US) | 2003-01-02 | — | — | EP | claimed |
| WO-2001074783-A1 | CYCLIC LACTAMS AS INHIBITORS OF A ΒΕΤΑ PROTEIN PRODUCTION | DUPONT PHARMACEUTICALS COMPANY (US) | 2001-10-11 | — | — | WO | claimed |
| EP-1268433-A1 | CYCLIC LACTAMS AS INHIBITORS OF A-BETA-PROTEIN PRODUCTION | Bristol-Myers Squibb Pharma Company (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001074783-A1 | CYCLIC LACTAMS AS INHIBITORS OF A ΒΕΤΑ PROTEIN PRODUCTION | DUPONT PHARMACEUTICALS COMPANY (US) | 2001-10-11 | — | — | WO | disclosed |