Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 3/20 | 0.34 |
| ▸ | CCKAR | P32238 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | NOTCH1 | P46531 | 4/20 | 0.32 |
| ▸ | NOTCH3 | Q9UM47 | 4/20 | 0.32 |
| ▸ | OXTR | P30559 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6954233 | 0.88 | NOTCH1 (0.35) | CCKBRCCKARNOTCH1NOTCH3DGAT1 | |
| SCHEMBL6949634 | 0.88 | NOTCH1 (0.39) | CCKBRALDH1A1KMT2APSEN1PSEN2 | |
| SCHEMBL3582955 | 0.78 | BDKRB1 (0.47) | CCKBRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6948348 | 0.75 | NOTCH1 (0.40) | KMT2ANOTCH1NOTCH3 | |
| SCHEMBL13502693 | 0.72 | CCKBR (0.42) | CCKBRCCKARNOTCH1NOTCH3 | |
| SCHEMBL6954236 | 0.71 | CCKAR (0.38) | CCKBRCCKARNOTCH1NOTCH3 | |
| SCHEMBL6948349 | 0.71 | CCKBR (0.39) | CCKBRCCKARPSEN1PSEN2APH1B | |
| SCHEMBL3594079 | 0.68 | PSEN1 (0.40) | CCKBRALDH1A1KMT2APSEN1PSEN2 | |
| SCHEMBL3596462 | 0.68 | XIAP (0.37) | CCKARPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6985672 | 0.66 | NOTCH1 (0.38) | CCKBRPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268433-A1 | CYCLIC LACTAMS AS INHIBITORS OF A-BETA-PROTEIN PRODUCTION | Bristol-Myers Squibb Pharma Company (US) | 2003-01-02 | — | — | EP | claimed |
| WO-2001074783-A1 | CYCLIC LACTAMS AS INHIBITORS OF A ΒΕΤΑ PROTEIN PRODUCTION | DUPONT PHARMACEUTICALS COMPANY (US) | 2001-10-11 | — | — | WO | claimed |
| EP-1268433-A1 | CYCLIC LACTAMS AS INHIBITORS OF A-BETA-PROTEIN PRODUCTION | Bristol-Myers Squibb Pharma Company (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001074783-A1 | CYCLIC LACTAMS AS INHIBITORS OF A ΒΕΤΑ PROTEIN PRODUCTION | DUPONT PHARMACEUTICALS COMPANY (US) | 2001-10-11 | — | — | WO | disclosed |