Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.48 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.48 |
| ▸ | ADH5 | P11766 | 6/20 | 0.47 |
| ▸ | TNIK | Q9UKE5 | 4/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6952054 | 0.90 | TNIK (0.42) | MAP2K1MAP2K2ADH5TNIKPDE4A | |
| SCHEMBL6944113 | 0.88 | MAP2K1 (0.59) | MAP2K1MAP2K2ADH5TNIKSTING1 | |
| SCHEMBL6952545 | 0.83 | MAP2K1 (0.50) | MAP2K1MAP2K2MEN1KMT2A | |
| SCHEMBL6945667 | 0.81 | MAP2K1 (0.56) | MAP2K1MAP2K2MEN1MAPK1KMT2A | |
| SCHEMBL3850436 | 0.78 | ADH5 (0.67) | ADH5PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6035670 | 0.75 | MAP2K1 (0.59) | MAP2K1MAP2K2MAPTMEN1MAPK1 | |
| SCHEMBL4851710 | 0.75 | MAP2K1 (0.78) | MAP2K1MAP2K2MEN1KMT2A | |
| SCHEMBL29425477 | 0.75 | MAP2K1 (0.78) | MAP2K1MAP2K2MEN1KMT2A | |
| SCHEMBL6948250 | 0.73 | MAP2K1 (0.56) | MAP2K1MAP2K2MAPTDHODHMEN1 | |
| SCHEMBL4733021 | 0.73 | MAP2K1 (0.52) | MAP2K1MAP2K2DHODHMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202724-B1 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER LAMBERT CO (US) | 2003-10-01 | — | — | EP | claimed |
| JP-2003504401-A | — | — | 2003-02-04 | — | — | JP | claimed |
| EP-1202724-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2002-05-08 | — | — | EP | claimed |
| EP-1150950-A2 | ANTHRANILIC ACID DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 2001-11-07 | — | — | EP | claimed |
| WO-2001005393-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-01-25 | — | — | WO | claimed |
| WO-2000041505-A2 | ANTHRANILIC ACID DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 2000-07-20 | — | — | WO | claimed |