Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 5/20 | 0.42 |
| ▸ | ADH5 | P11766 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | F9 | P00740 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6948718 | 0.90 | MAP2K1 (0.48) | TNIKADH5LMNAMAPTPDE4A | |
| SCHEMBL6952545 | 0.85 | MAP2K1 (0.50) | MAP2K1MAP2K2 | |
| SCHEMBL6945667 | 0.83 | MAP2K1 (0.56) | MAP2K1MAP2K2 | |
| SCHEMBL6944113 | 0.78 | MAP2K1 (0.59) | TNIKADH5MAP2K1MAP2K2F9 | |
| SCHEMBL5388138 | 0.76 | MAP2K1 (0.60) | MAP2K1MAP2K2 | |
| SCHEMBL6948913 | 0.74 | MAP2K1 (0.43) | MAPTMAP2K1MAP2K2 | |
| SCHEMBL6946266 | 0.73 | MAP2K1 (0.42) | MAP2K1MAP2K2 | |
| SCHEMBL6945746 | 0.73 | MAP2K1 (0.42) | MAP2K1MAP2K2 | |
| SCHEMBL6945853 | 0.72 | MAP2K1 (0.41) | MAP2K1MAP2K2 | |
| SCHEMBL7806590 | 0.71 | MEN1 (0.44) | TNIKADH5LMNAMAPTPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202724-B1 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER LAMBERT CO (US) | 2003-10-01 | — | — | EP | claimed |
| JP-2003504401-A | — | — | 2003-02-04 | — | — | JP | claimed |
| EP-1202724-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2002-05-08 | — | — | EP | claimed |
| EP-1150950-A2 | ANTHRANILIC ACID DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 2001-11-07 | — | — | EP | claimed |
| WO-2001005393-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-01-25 | — | — | WO | claimed |
| WO-2000041505-A2 | ANTHRANILIC ACID DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 2000-07-20 | — | — | WO | claimed |