Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | TKT | P29401 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7073069 | 0.90 | RAD52 (0.46) | RAD52KDM4E | |
| SCHEMBL4957388 | 0.86 | KDM4E (0.38) | KDM4E | |
| SCHEMBL9598378 | 0.83 | KDM4C (0.35) | KDM4CHTTKDM4ESMN1; SMN2 | |
| SCHEMBL4955468 | 0.83 | KDM4C (0.32) | KDM4C | |
| SCHEMBL7851162 | 0.80 | PARP1 (0.43) | KDM4C | |
| SCHEMBL4962380 | 0.79 | PI4KA (0.48) | KDM4C | |
| SCHEMBL5062600 | 0.79 | DDAH1 (0.42) | KDM4CHTT | |
| SCHEMBL9572852 | 0.79 | EGFR (0.31) | — | |
| SCHEMBL4957459 | 0.79 | EGFR (0.31) | — | |
| SCHEMBL6946791 | 0.78 | RAB9A (0.54) | HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349857-A1 | PURINE DERIVATIVES AS PURINERGIC RECEPTOR ANTAGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002055521-A1 | PURINE DERIVATIVES AS PURINERGIC RECEPTOR ANTAGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2002-07-18 | — | — | WO | disclosed |