Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9026938 | 0.77 | KDM4E (0.31) | GAAMEN1KMT2A | |
| SCHEMBL15127181 | 0.72 | TSHR (0.42) | GAAMEN1KMT2ATSHRADRA2A | |
| SCHEMBL6802919 | 0.69 | GAA (0.47) | GAAMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL27655266 | 0.68 | ALDH1A1 (0.42) | GAAALDH1A1TSHR | |
| SCHEMBL11317425 | 0.65 | ALDH1A1 (0.39) | GAAALDH1A1TSHR | |
| SCHEMBL7760107 | 0.65 | ALDH1A1 (0.39) | GAAALDH1A1TSHR | |
| SCHEMBL6952162 | 0.63 | GAA (0.54) | GAAMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL28323118 | 0.60 | ALDH1A1 (0.42) | GAAALDH1A1TSHR | |
| SCHEMBL6129391 | 0.60 | ALDH1A1 (0.42) | GAAALDH1A1TSHR | |
| SCHEMBL7637509 | 0.60 | ALDH1A1 (0.37) | GAAMEN1KMT2AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140899-B1 | PROCESS FOR PREPARING TRICYCLIC COMPOUNDS HAVING ANTIHISTAMINIC ACTIVITY | SCHERING CORP (US) | 2003-09-10 | — | — | EP | disclosed |
| US-6271378-B1 | Process for preparing tricyclic compounds having antihistaminic activity | SCHERING CORPORATION | 2001-08-07 | — | — | US | disclosed |
| US-5608056-A | Substituted 3-pyrrolidinylthio-carbapenems as antimicrobial agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| WO-1996010559-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-04-11 | — | — | WO | disclosed |
| WO-1993021186-A1 | SUBSTITUTED 3-PYRROLIDINYLTHIO-CARBAPENEMS AS ANTIMICROBIAL AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-10-28 | — | — | WO | disclosed |