Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.40 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.40 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.40 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.40 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.40 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.40 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.40 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27775659 | 0.88 | SMN1; SMN2 (0.53) | SMN1; SMN2PKMPOLBTUBB4ATUBB | |
| SCHEMBL7657936 | 0.81 | SMN1; SMN2 (0.46) | SMN1; SMN2PKMPOLBABCB1ABCC1 | |
| SCHEMBL6948699 | 0.80 | SMN1; SMN2 (0.50) | SMN1; SMN2PKMPOLBTUBB4ATUBB | |
| SCHEMBL6953716 | 0.77 | PDE5A (0.44) | SMN1; SMN2PKMPOLBTUBB4ATUBB | |
| SCHEMBL31451828 | 0.76 | SMN1; SMN2 (0.49) | SMN1; SMN2PKMPOLBTUBB4ATUBB | |
| SCHEMBL5963109 | 0.75 | PKM (0.59) | PKMTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL29033623 | 0.74 | PKM (0.50) | SMN1; SMN2PKMPOLBTUBB4ATUBB | |
| SCHEMBL29033599 | 0.74 | KDM4E (0.54) | PKMPOLBTUBB4ATUBBTUBA3C | |
| SCHEMBL6902580 | 0.72 | KMT2A (0.58) | SMN1; SMN2POLBTUBB4ATUBBTUBA3C | |
| SCHEMBL30740961 | 0.72 | TPMT (0.59) | VCAM1PKMABCB1ABCC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0887344-B1 | Quinolines and quinazolines useful in therapy | PFIZER LTD (GB) | 2003-12-03 | — | — | EP | disclosed |
| US-6417194-B1 | TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | PFIZER, INC. | 2002-07-09 | — | — | US | disclosed |
| US-6048864-A | Quinolines and quinazolines useful in therapy | PFIZER INC (US) | 2000-04-11 | — | — | US | disclosed |
| EP-0887344-A1 | Quinolines and quinazolines useful in therapy | Pfizer Limited (GB) | 1998-12-30 | — | — | EP | disclosed |