Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5072892 | 0.84 | PKM (0.66) | PKMKDM4ELMNAALDH1A1POLB | |
| SCHEMBL13745755 | 0.81 | PKM (0.59) | PKMKDM4ELMNAALDH1A1POLB | |
| Formic Acid SCHEMBL5082474 | 0.79 | PKM (0.60) | PKMKDM4ELMNAALDH1A1POLB | |
| SCHEMBL5364591 | 0.77 | TDP1 (0.62) | PKMKDM4ELMNAALDH1A1POLB | |
| SCHEMBL6941883 | 0.73 | KDM4E (0.52) | PKMKDM4ELMNAALDH1A1POLB | |
| SCHEMBL25230284 | 0.73 | KMT2A (0.48) | PKMKDM4ELMNAALDH1A1RXFP1 | |
| SCHEMBL12741415 | 0.72 | OPRL1 (0.53) | PKM | |
| SCHEMBL3518823 | 0.71 | SIGMAR1 (0.38) | LMNAALDH1A1 | |
| SCHEMBL24424324 | 0.71 | POLB (0.56) | POLBMAPTRXFP1KMT2A | |
| SCHEMBL24422923 | 0.71 | POLB (0.56) | POLBMAPTRXFP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244450-A4 | 8-AZA-BICYCLO[3.2.1]OCTANE NMDA/NR2B ANTAGONISTS | MERCK & CO INC (US) | 2003-03-19 | — | — | EP | disclosed |
| EP-1244450-A1 | 8-AZA-BICYCLO[3.2.1]OCTANE NMDA/NR2B ANTAGONISTS | Merck & Co., Inc. (US) | 2002-10-02 | — | — | EP | disclosed |
| US-6432976-B1 | ANALGESICS; SIDE EFFECT REDUCTION | MERCK & CO., INC. | 2002-08-13 | — | — | US | disclosed |
| WO-2001032179-A1 | 8-AZA-BICYCLO[3.2.1]OCTANE NMDA/NR2B ANTAGONISTS | MERCK & CO., INC. (US) | 2001-05-10 | — | — | WO | disclosed |