Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 8/20 | 0.44 |
| ▸ | HTR4 | Q13639 | 6/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 6/20 | 0.41 |
| ▸ | DRD4 | P21917 | 6/20 | 0.41 |
| ▸ | DRD3 | P35462 | 4/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7257588 | 0.88 | HTR4 (0.44) | ACHEHTR4KCNH2DRD2DRD4 | |
| SCHEMBL6328740 | 0.82 | HDAC3 (0.50) | ACHEHTR4KCNH2DRD2DRD4 | |
| SCHEMBL6328978 | 0.78 | HTR4 (0.54) | ACHEHTR4SIGMAR1 | |
| SCHEMBL6336358 | 0.77 | HTR4 (0.56) | ACHEHTR4DRD2DRD4DRD3 | |
| SCHEMBL6335710 | 0.76 | KCNH2 (0.60) | HTR4KCNH2DRD2DRD4DRD3 | |
| SCHEMBL6330942 | 0.75 | DRD2 (0.54) | ACHEHTR4KCNH2DRD2DRD4 | |
| SCHEMBL6328378 | 0.74 | CXCR4 (0.52) | HTR4KCNH2DRD2DRD4DRD3 | |
| SCHEMBL6329054 | 0.74 | TP53 (0.57) | ACHEHTR4KCNH2DRD2DRD4 | |
| SCHEMBL6329269 | 0.74 | DRD2 (0.58) | ACHEHTR4DRD2DRD4DRD3 | |
| SCHEMBL6326628 | 0.74 | HTR4 (0.49) | ACHEHTR4SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1325921-A2 | Oxo or oxy-pyridine compounds as 5-HT4 receptor modulators | Pfizer Inc. (US) | 2003-07-09 | — | — | EP | disclosed |