Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 2/20 | 0.40 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6954220 | 0.93 | KCNK3 (0.40) | KCNK3KCNK9ENPP2MCL1KDM4E | |
| SCHEMBL6954922 | 0.92 | PKM (0.41) | ENPP2KDM4EMEN1MAPTHPGD | |
| SCHEMBL6953897 | 0.89 | ENPP2 (0.44) | KCNK3KCNK9ENPP2MCL1KDM4E | |
| SCHEMBL6954685 | 0.89 | MEN1 (0.43) | KDM4EMEN1MAPTHPGDKMT2A | |
| SCHEMBL7498695 | 0.88 | KDM4E (0.44) | KCNK3KCNK9ENPP2MCL1KDM4E | |
| SCHEMBL6954781 | 0.87 | KCNK3 (0.42) | KCNK3KCNK9ENPP2MCL1KDM4E | |
| SCHEMBL7505803 | 0.85 | KDM4E (0.47) | KCNK3KCNK9MCL1KDM4EMEN1 | |
| SCHEMBL6949204 | 0.85 | ENPP2 (0.38) | ENPP2KDM4EMEN1MAPTHPGD | |
| SCHEMBL7507549 | 0.84 | HPGD (0.47) | MCL1KDM4EMEN1LMNAMAPT | |
| SCHEMBL7507930 | 0.84 | KCNK3 (0.49) | KCNK3KCNK9ENPP2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0985666-B1 | Substituted indole compounds as COX-2 inhibitors | PFIZER (US) | 2003-11-05 | — | — | EP | claimed |
| US-6277878-B1 | ANTIINFLAMMATORY AGENTS; ANALGESICS | PFIZER INC | 2001-08-21 | — | — | US | claimed |
| EP-0985666-A1 | Substituted indole compounds as COX-2 inhibitors | PFIZER INC. (US) | 2000-03-15 | — | — | EP | claimed |
| EP-0985666-B1 | Substituted indole compounds as COX-2 inhibitors | PFIZER (US) | 2003-11-05 | — | — | EP | disclosed |
| US-6277878-B1 | ANTIINFLAMMATORY AGENTS; ANALGESICS | PFIZER INC | 2001-08-21 | — | — | US | disclosed |
| EP-0985666-A1 | Substituted indole compounds as COX-2 inhibitors | PFIZER INC. (US) | 2000-03-15 | — | — | EP | disclosed |