Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 8/20 | 0.50 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.45 |
| ▸ | NAMPT | P43490 | 9/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6952862 | 0.90 | IGF1R (0.50) | IGF1RTBK1NAMPTGSK3B | |
| SCHEMBL6947662 | 0.88 | GSK3B (0.58) | IGF1RTBK1NAMPTGSK3B | |
| SCHEMBL7853353 | 0.83 | IGF1R (0.46) | IGF1RTBK1GSK3B | |
| SCHEMBL5263041 | 0.81 | ALDH1A1 (0.54) | IGF1RNAMPT | |
| SCHEMBL5261586 | 0.81 | IGF1R (0.48) | IGF1RTBK1GSK3B | |
| SCHEMBL5259735 | 0.79 | BRAF (0.51) | IGF1RGSK3B | |
| SCHEMBL7007966 | 0.72 | NAMPT (0.49) | NAMPT | |
| SCHEMBL6646546 | 0.71 | NAMPT (0.56) | NAMPT | |
| SCHEMBL5259487 | 0.70 | NPC1 (0.51) | IGF1RNAMPT | |
| SCHEMBL5261848 | 0.69 | IGF1R (0.74) | IGF1RGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003525278-A | — | — | 2003-08-26 | — | — | JP | claimed |
| EP-1268444-A1 | 2,4-DI(HETERO-)ARYLAMINO(-OXY)-5-SUBSTITUTED PYRMIDINES AS ANTINEOPLASTIC AGENTS | AstraZeneca AB (SE) | 2003-01-02 | — | — | EP | claimed |
| WO-2001064655-A1 | 2, 4-DI(HETERO-)ARYLAMINO (-OXY)-5-SUBSTITUTED PYRIMIDINES AS ANTINEOPLASTIC AGENTS | ASTRAZENECA AB (SE) | 2001-09-07 | — | — | WO | claimed |