Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 19/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6226700 | 0.79 | SMN1; SMN2 (0.54) | NAMPTNPC1 | |
| SCHEMBL6947662 | 0.77 | GSK3B (0.58) | NAMPT | |
| SCHEMBL7011089 | 0.76 | NAMPT (0.65) | NAMPT | |
| SCHEMBL6952862 | 0.74 | IGF1R (0.50) | NAMPT | |
| SCHEMBL6949387 | 0.72 | IGF1R (0.50) | NAMPT | |
| SCHEMBL8780738 | 0.71 | NAMPT (0.71) | NAMPT | |
| SCHEMBL6646546 | 0.71 | NAMPT (0.56) | NAMPT | |
| SCHEMBL1499531 | 0.71 | NAMPT (0.55) | NAMPTNPC1RAB9A | |
| SCHEMBL7004700 | 0.68 | MAPT (0.57) | NAMPTNPC1RAB9A | |
| SCHEMBL2447886 | 0.66 | NPC1 (0.74) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268445-A1 | 4-AMINO-5-CYANO-2-ANILINO-PYRIMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS OF CELL-CYCLE KINASES | AstraZeneca AB (SE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001072717-A1 | 4-AMINO-5-CYANO-2-ANILINO-PYRIMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS OF CELL-CYCLE KINASES | ASTRAZENECA AB (SE) | 2001-10-04 | — | — | WO | disclosed |