Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A known ✓ | Q03164 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 9/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6949525 | 1.00 | MEN1 (0.48) | MEN1KMT2ALMNAATMBLM | |
| Fumaric Acid SCHEMBL8671251 | 0.99 | MEN1 (0.48) | MEN1KMT2ALMNAATMBLM | |
| Fumaric Acid SCHEMBL8671252 | 0.99 | MEN1 (0.48) | MEN1KMT2ALMNAATMBLM | |
| SCHEMBL6943201 | 0.92 | MEN1 (0.50) | MEN1KMT2ALMNAATMALDH1A1 | |
| Fumaric Acid SCHEMBL8848411 | 0.89 | TBXA2R (0.57) | MEN1KMT2ALMNAATMBLM | |
| Fumaric Acid SCHEMBL8848410 | 0.89 | TBXA2R (0.57) | MEN1KMT2ALMNAATMBLM | |
| Fumaric Acid SCHEMBL8670308 | 0.89 | TBXA2R (0.47) | MEN1KMT2ALMNAATMBLM | |
| Fumaric Acid SCHEMBL8670305 | 0.89 | TBXA2R (0.47) | MEN1KMT2ALMNAATMBLM | |
| Fumaric Acid SCHEMBL8669278 | 0.82 | SMN1; SMN2 (0.48) | MEN1KMT2ALMNAATMBLM | |
| Fumaric Acid SCHEMBL8669282 | 0.82 | SMN1; SMN2 (0.48) | MEN1KMT2ALMNAATMBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709378-B1 | Aminoalkyloximes, a process for their preparation, their use as medicaments and intermediate compounds | AVENTIS PHARMA INC (US) | 2003-03-19 | — | — | EP | claimed |
| US-5696142-A | TREATING DEPRESSION, OBSESSIVE COMPULSIVE DISORDERS | HOECHST MARION ROUSSEL, INC. (US) | 1997-12-09 | — | — | US | claimed |
| EP-0709378-A2 | Aminoalkyloximes, a process for their preparation, their use as medicaments and intermediate compounds | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1996-05-01 | — | — | EP | claimed |