Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 2/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | IL6 | P05231 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7464132 | 0.93 | KDM4E (0.44) | CHRM4KDM4ENPC1RAB9AKMT2A | |
| SCHEMBL6949028 | 0.81 | KDM4E (0.46) | HIF1AEPAS1KDM4ENPC1RAB9A | |
| SCHEMBL12965907 | 0.81 | KDM4E (0.45) | HIF1AEPAS1KDM4EIL6TLR7 | |
| Trifluoroacetic Acid SCHEMBL2086389 | 0.79 | MAPK1 (0.50) | F11KLKB1KDM4ENPC1RAB9A | |
| SCHEMBL9733579 | 0.77 | HRH3 (0.57) | HIF1AEPAS1KDM4ENPC1RAB9A | |
| SCHEMBL22465802 | 0.77 | KDM4E (0.44) | CHRM4HIF1AEPAS1KDM4ENPC1 | |
| SCHEMBL7078749 | 0.77 | CKS1B (0.48) | CHRM4KDM4E | |
| SCHEMBL1857662 | 0.76 | HRH3 (0.59) | KDM4ENPC1RAB9AKMT2AMAPK1 | |
| SCHEMBL9202121 | 0.75 | CHKA (0.55) | HIF1AEPAS1KDM4ENPC1RAB9A | |
| SCHEMBL12965883 | 0.75 | KDM4E (0.64) | CHRM4KDM4EKMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6649627-B1 | N-Substituted with 1- (pyrid-2-yl)-piperidine-4-yl radical; gastrointestinal and psychological disorder treatment; antidiabetic tocolytic, and antidepressant agents; irritable bowel syndrome, glaucoma and dysmenorrhoea | SANOFI-SYNTHELABO (FR) | 2003-11-18 | — | — | US | disclosed |