Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 5/20 | 0.41 |
| ▸ | PTPRC | P08575 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 4/20 | 0.37 |
| ▸ | PTPRB | P23467 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7884519 | 0.82 | PTPN1 (0.46) | PTPN1PTPRCALDH1A1RECQLMMP8 | |
| SCHEMBL7879135 | 0.80 | PTPN1 (0.43) | PTPN1PTPRCALDH1A1RECQLMMP8 | |
| SCHEMBL1124743 | 0.80 | TSHR (0.44) | ALDH1A1KMT2ANR1H4ACSS2SMN1; SMN2 | |
| SCHEMBL7888188 | 0.79 | PTPN1 (0.40) | PTPN1PTPRCALDH1A1RECQLMMP8 | |
| SCHEMBL6951579 | 0.73 | ALDH1A1 (0.41) | ALDH1A1RECQLARPTPRBNR1H4 | |
| SCHEMBL20326484 | 0.73 | LMNA (0.56) | PTPN1PTPRCALDH1A1PTPRBNR1H4 | |
| SCHEMBL6950120 | 0.73 | PTPRB (0.34) | ALDH1A1PTPRBTSHR | |
| SCHEMBL28943134 | 0.72 | LMNA (0.48) | ALDH1A1RECQLMMP8KMT2ATAAR1 | |
| SCHEMBL8743568 | 0.72 | ALDH1A1 (0.47) | ALDH1A1RECQLMMP8KMT2ATAAR1 | |
| SCHEMBL6946520 | 0.72 | PTPN1 (0.69) | PTPN1PTPRCPTPRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115729-B1 | PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PTP-1B | MERCK FROSST CANADA INC (CA) | 2003-02-19 | — | — | EP | disclosed |
| US-6174874-B1 | ANTIDIABETIC,-CARCINOGENIC AGENTS; IMPROVING GLUCOSE TOLERANCE/INSULIN-SENSITIVITY; PREVENTING/TREATING OBESITY AND NEURODEGENERATIVE DISEASES; E.G. 1,3-BIS-((PHOSPHONODI-FLUOROMETHYL)PHENYL)-2-DICARBOXYPROPANE | MERCK FROSST CANADA & CO. (CA) | 2001-01-16 | — | — | US | disclosed |