Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.44 |
| ▸ | ANPEP | P15144 | 3/20 | 0.41 |
| ▸ | RNPEP | Q9H4A4 | 3/20 | 0.41 |
| ▸ | DNPEP | Q9ULA0 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24539765 | 0.80 | EPHX1 (0.54) | SMN1; SMN2RAB9AGAAMMP2MMP8 | |
| SCHEMBL29980822 | 0.76 | EPHX1 (0.68) | SMN1; SMN2ALDH1A1CYP2C19EPHX1GPR35 | |
| SCHEMBL26157371 | 0.73 | EPHX1 (0.58) | SMN1; SMN2RAB9AGAAMMP2MMP8 | |
| SCHEMBL16363611 | 0.73 | EPHX1 (0.54) | SMN1; SMN2RAB9AGAAMMP2MMP8 | |
| SCHEMBL21786685 | 0.73 | EPHX1 (0.46) | SMN1; SMN2RAB9AGAAMMP2MMP8 | |
| SCHEMBL7199940 | 0.71 | TSHR (0.44) | RAB9AMMP2ALDH1A1CYP2C19EPHX1 | |
| SCHEMBL5158628 | 0.71 | NAAA (0.41) | SMN1; SMN2RAB9AGAAMMP2MMP8 | |
| SCHEMBL24539766 | 0.71 | EPHX1 (0.51) | SMN1; SMN2RAB9AGAAMMP2MMP8 | |
| SCHEMBL19429723 | 0.71 | EPHX1 (0.44) | SMN1; SMN2RAB9AGAAMMP2MMP8 | |
| SCHEMBL6385930 | 0.70 | HSD17B10 (0.62) | SMN1; SMN2RAB9AGAAMMP2MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268433-A1 | CYCLIC LACTAMS AS INHIBITORS OF A-BETA-PROTEIN PRODUCTION | Bristol-Myers Squibb Pharma Company (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001074783-A1 | CYCLIC LACTAMS AS INHIBITORS OF A ΒΕΤΑ PROTEIN PRODUCTION | DUPONT PHARMACEUTICALS COMPANY (US) | 2001-10-11 | — | — | WO | disclosed |