Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 7/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.40 |
| ▸ | RAF1 | P04049 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.34 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6950337 | 0.78 | MAPK14 (0.48) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL6950332 | 0.77 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7498393 | 0.77 | MAPK14 (0.39) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7979937 | 0.73 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7991937 | 0.70 | MAPK14 (0.67) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7991981 | 0.70 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7993953 | 0.69 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7994010 | 0.67 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7994015 | 0.67 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7990822 | 0.67 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1196169-A4 | COMPOUNDS HAVING CYTOKINE INHIBITORY ACTIVITY | MERCK & CO INC (US) | 2003-04-02 | — | — | EP | disclosed |
| EP-1196169-A1 | COMPOUNDS HAVING CYTOKINE INHIBITORY ACTIVITY | Merck & Co., Inc. (US) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001001988-A1 | COMPOUNDS HAVING CYTOKINE INHIBITORY ACTIVITY | MERCK & CO., INC. (US) | 2001-01-11 | — | — | WO | disclosed |