Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | GRK2 | P25098 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6950332 | 0.84 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL7979937 | 0.79 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL6950335 | 0.78 | MAPK14 (0.40) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL7498398 | 0.78 | MAPK14 (0.46) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL7991937 | 0.77 | MAPK14 (0.67) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL7994015 | 0.76 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL7994010 | 0.76 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL7993953 | 0.74 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL7747142 | 0.73 | MAPK14 (0.59) | MAPK14MAPK13MAPK12MAPK11DRD2 | |
| SCHEMBL7075425 | 0.73 | MAPK14 (0.42) | MAPK14MAPK13MAPK12MAPK11RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1196169-A4 | COMPOUNDS HAVING CYTOKINE INHIBITORY ACTIVITY | MERCK & CO INC (US) | 2003-04-02 | — | — | EP | disclosed |
| EP-1196169-A1 | COMPOUNDS HAVING CYTOKINE INHIBITORY ACTIVITY | Merck & Co., Inc. (US) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001001988-A1 | COMPOUNDS HAVING CYTOKINE INHIBITORY ACTIVITY | MERCK & CO., INC. (US) | 2001-01-11 | — | — | WO | disclosed |