Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.37 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.37 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947271 | 0.88 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL8011517 | 0.76 | MAPK14 (0.52) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4025102 | 0.76 | MAPK14 (0.52) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4031135 | 0.75 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL8603751 | 0.75 | BTK (0.47) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL8604095 | 0.75 | BTK (0.47) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL6950337 | 0.73 | MAPK14 (0.48) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4027239 | 0.71 | MAPK14 (0.43) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4035352 | 0.70 | MAPK14 (0.42) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL8605126 | 0.69 | BTK (0.46) | MAPK14MAPK13MAPK12MAPK11RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1196169-A4 | COMPOUNDS HAVING CYTOKINE INHIBITORY ACTIVITY | MERCK & CO INC (US) | 2003-04-02 | — | — | EP | disclosed |
| EP-1196169-A1 | COMPOUNDS HAVING CYTOKINE INHIBITORY ACTIVITY | Merck & Co., Inc. (US) | 2002-04-17 | — | — | EP | disclosed |
| US-6291457-B1 | SUBSTITUTED IMIDAZOLE COMPOUNDS | MERCK & CO., INC. | 2001-09-18 | — | — | US | disclosed |
| WO-2001001988-A1 | COMPOUNDS HAVING CYTOKINE INHIBITORY ACTIVITY | MERCK & CO., INC. (US) | 2001-01-11 | — | — | WO | disclosed |