SCHEMBL6950358

SCHEMBL6950358

O[C@@H]1CCc2ccc(F)cc2C1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1D P28221 1/20 0.43
HTR1B P28222 1/20 0.43
CYP1A2 P05177 1/20 0.42
CYP11B1 P15538 1/20 0.42
CYP11B2 P19099 1/20 0.42
DRD2 P14416 8/20 0.41
DRD3 P35462 8/20 0.41
DRD4 P21917 4/20 0.41
HDAC8 Q9BY41 2/20 0.40
HDAC6 Q9UBN7 1/20 0.40
PRMT5 O14744 1/20 0.38
HTR1A P08908 3/20 0.38
HTR2A P28223 2/20 0.38
SLC6A4 P31645 2/20 0.38
HTR2B P41595 2/20 0.38
HTR7 P34969 1/20 0.38
ADRB2 P07550 2/20 0.37
MLNR O43193 1/20 0.37
ADRB1 P08588 1/20 0.37
ADRA2A P08913 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6950364 1.00 HTR1D (0.43) HTR1DHTR1BCYP1A2CYP11B1CYP11B2
SCHEMBL4621351 0.92 HTR1D (0.50) HTR1DHTR1BCYP1A2CYP11B1CYP11B2
SCHEMBL6952592 0.92 HTR1D (0.50) HTR1DHTR1BCYP1A2CYP11B1CYP11B2
SCHEMBL3964498 0.84 SLC6A4 (0.42) HTR1DHTR1BDRD2DRD3HTR1A
SCHEMBL12993448 0.84 SLC6A4 (0.42) HTR1DHTR1BDRD2DRD3HTR1A
SCHEMBL30199160 0.78 DRD3 (0.65) CYP1A2DRD2DRD3DRD4HTR1A
SCHEMBL2564622 0.78 DRD3 (0.65) CYP1A2DRD2DRD3DRD4HTR1A
SCHEMBL6948524 0.78 CYP1A2 (0.41) CYP1A2CYP11B1CYP11B2DRD2DRD3
SCHEMBL6951058 0.78 CYP1A2 (0.41) CYP1A2CYP11B1CYP11B2DRD2DRD3
SCHEMBL16233582 0.77 HTR1D (0.46) HTR1DHTR1BDRD2DRD3DRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0757677-B1 BENZOCYCLOHEXYLIMIDAZOLETHIONE DERIVATIVES SYNTEX LLC (US) 2003-06-18 EP disclosed
US-5719280-A REACTING AMINE SUBSTITUTED BENZOCYCLOALKANE WITH DIALKYLOXYACETALDEHYDE IN PRESENCE OF REDUCING AGENT OR CATALYTIC HYDROGENATION, TREATING WITH THIOCYANIC ACID SYNTEX (U.S.A.) INC. (US) 1998-02-17 US disclosed
EP-0757677-A1 BENZOCYCLOALKYLAZOLETHIONE DERIVATIVES SYNTEX (U.S.A.) INC. (US) 1997-02-12 EP disclosed
US-5538988-A CARDIOVASCULAR DISORDERS AND DOPAMINE HYDROLASE ENZYME INHIBITORS SYNTEX (U.S.A.) INC. 1996-07-23 US disclosed
WO-1995029165-A2 BENZOCYCLOALKYLAZ0LETHIONE DERIVATIVES AS DOPAMIN BETA-HYDROXYLASE INHIBITORS SYNTEX (U.S.A.) INC. (US) 1995-11-02 WO disclosed